Status of the 68 genes from Sjöblom et al. list (23) in the subjects of this study.

<p>The most frequently deleted genes in our samples were <i>EPHB6, EXOC4 (SEC8L1), GNAS, MLL3 and TBX22</i>. The most frequently amplified genes were <i>HAPLN1, ADAM29, SMAD2 and SMAD4</i>. Gene names are according to the official HUGO Gene Nomenclature Committee and the old names in parentheses are from Sjöblom et al.</p

Number and frequency of aberrations per chromosome.

<p>*3(3) means 3 amplification in 3 cases; 8 (5) means 8 deletions in 5 cases from total of 15 for the calculated frequency.</p

Clinical and demographic characteristics of the 15 patients enrolled in this study.

<p>Clinical and demographic characteristics of the 15 patients enrolled in this study.</p

Atrial Fibrillation and Colonic Neoplasia in African Americans

<div><p>Background</p><p>Colorectal cancer (CRC) and atrial fibrillation/flutter (AF) share several risk factors including increasing age and obesity. However, the association between CRC and AF has not been thoroughly examined, especially in African Americans. In this study we aimed to assess the prevalence of AF and its risk factors in colorectal neoplasia in an African American.</p><p>Methods</p><p>We reviewed records of 527 African American patients diagnosed with CRC and 1008 patients diagnosed with benign colonic lesions at Howard University Hospital from January 2000 to December 2012. A control group of 731 hospitalized patients without any cancer or colonic lesion were randomly selected from the same time and age range, excluding patients who had diagnosis of both CRC and/or adenoma. The presence or absence of AF was based upon ICD-9 code documentation. The prevalence of AF in these three groups was compared by multivariate logistic regression.</p><p>Results</p><p>The prevalence of AF was highest among CRC patients (10%) followed by adenoma patients (7.2%) then the control group (5.4%, P for trend = 0.002). In the three groups of participants, older age (P<0.008) and heart failure (P<0.001) were significantly associated with higher risk of AF. After adjusting for these risk factors, CRC (OR: 1.4(95%CI):0.9–2.2, P = 0.2) and adenoma (OR: 1.1(95%CI):0.7–1.6, P = 0.7) were not significantly associated AF compared to control group.</p><p>Conclusions</p><p>AF is highly prevalent among CRC patients; 1 in 10 patients had AF in our study. The predictors of AF in CRC was similar to that in adenoma and other patients after adjustment for potential confounders suggesting that the increased AF risk in CRC is explained by higher prevalence of AF risk factors.</p></div

Bacterial phyla and genera distribution in healthy (Blue) and colon polyps (Red) patients’ samples based on 454 pyrosequencing data.

<p>Bacterial phyla and genera distribution in healthy (Blue) and colon polyps (Red) patients’ samples based on 454 pyrosequencing data.</p

Dendrogram reflecting the healthy (AFR001-006) and colon polyps (AFR007-012) samples clustering based on the 454 pyrosequencing data analyzed at the Operational Taxonomic Unit (OTU: sub-genus) level.

<p>Dendrogram reflecting the healthy (AFR001-006) and colon polyps (AFR007-012) samples clustering based on the 454 pyrosequencing data analyzed at the Operational Taxonomic Unit (OTU: sub-genus) level.</p

Number of aberrations and associations with clinical and demographical data.

<p>Number of aberrations and associations with clinical and demographical data.</p

MSI analysis and association with clinical and demographical parameters.

<p>MSI analysis and association with clinical and demographical parameters.</p

Dendrogram reflecting the healthy (AFR001-006) and colon polyps (AFR007-012) samples clustering based on the 454 pyrosequencing data analyzed at the genus level.

<p>Dendrogram reflecting the healthy (AFR001-006) and colon polyps (AFR007-012) samples clustering based on the 454 pyrosequencing data analyzed at the genus level.</p

Dendrogram of the samples’ clustering based on the global HITChip oligonucleotide probe signal intensities (AFR001-006; Healthy patients’ samples, AFR007-012: Polyp patients’ samples).

<p>Dendrogram of the samples’ clustering based on the global HITChip oligonucleotide probe signal intensities (AFR001-006; Healthy patients’ samples, AFR007-012: Polyp patients’ samples).</p